翻訳と辞書 Words near each other ・ Gluyas Williams ・ Glutamate 5-kinase ・ Glutamate aspartate transporter ・ Glutamate carboxypeptidase ・ Glutamate carboxypeptidase II ・ Glutamate decarboxylase ・ Glutamate dehydrogenase ・ Glutamate dehydrogenase 1 ・ Glutamate flavoring ・ Glutamate formimidoyltransferase ・ Glutamate hypothesis of schizophrenia ・ Glutamate N-acetyltransferase ・ Glutamate permease ・ Glutamate racemase ・ Glutamate receptor ・ Glutamate receptor-interacting protein ・ Glutamate synthase (ferredoxin) ・ Glutamate synthase (NADH) ・ Glutamate synthase (NADPH) ・ Glutamate-1-semialdehyde ・ Glutamate-1-semialdehyde 2,1-aminomutase ・ Glutamate-5-semialdehyde ・ Glutamate-5-semialdehyde dehydrogenase ・ Glutamate-glutamine cycle ・ Glutamatergic ・ Glutamate–cysteine ligase ・ Glutamate—ethylamine ligase ・ Glutamate—methylamine ligase ・ Glutamate—prephenate aminotransferase ・ Glutamate—putrescine ligase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Glutamate receptor-interacting protein ： ウィキペディア英語版 Glutamate receptor-interacting protein Glutamate receptor-interacting protein (GRIP) refers to either a family of proteins that bind to the glutamate receptor or specifically to the GRIP1 protein within this family. Proteins in the glutamate receptor-interacting protein (GRIP) family have been shown to interact with GluR2, a common subunit in the AMPA receptor. This subunit also interacts with other proteins such as protein interacting with C-kinase1 (PICK1) and N-ethylmaleimide-sensitive fusion protein (NSF). Studies have begun to elucidate its function; however, much is still to be learned about these proteins. == Discovery and history of GRIP 1 == The discovery of the Glutamate Receptor Interacting Protein (GRIP-1) came as a result of the observation that Glutamate Receptors, such as the NMDA receptor, cluster during a synapse. Shortly after this observation, researchers identified a region on the C-terminal region of NMDA receptors called the tSXV motif that has the ability to bind to the PDZ domain of the PSD-95 protein. Research on NMDA receptor localization paved the way for research on non-NMDA receptors such as AMPA receptors. Similar to NMDA receptors, it was discovered that AMPA receptors localize in the synaptic terminal of neurons in the central nervous system. By using GFP (green fluorescent protein) antibodies that correspond to the GRIP protein, researchers were able to use fluorescence to determine the location of GRIP in hippocampal neurons. Another GFP antibody was then used to label the GluR2 subunit of AMPA receptors.〔 By using immunocytochemistry and comparing the location of GRIP and AMPA receptors it was determined that GRIP and AMPA receptors experience colocalization in hippocampal neurons.〔 These findings confirmed the initial hypothesis that the GRIP protein plays an important role in binding AMPA receptors to excitatory synapses. The structure of GRIP contains seven PDZ domains and binds to the C-terminus of the GluR2 subunit of AMPA receptors.〔 Although the number of PDZ domains is different for the proteins PSD-95 and GRIP, the PDZ domain is a common structural motif in proteins that help mediate protein-protein interactions.〔Lee, H., & Zheng, J. (2010, May 28). PDZ domains and their binding partners: Structure, specificity, and modification. Retrieved November 9, 2014, from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891790/〕 The AMPA receptor amino acid sequence that the GRIP protein binds to is ESVKI. The conserved serine amino acid in the C- terminus of both AMPA and NMDA receptors suggests that it plays an important role in facilitating the interaction for GRIP and PSD-95.〔Ehlers, M., Mammen, A., Lau, L., & Huganir, R. (1998). Synaptic targeting of glutamate receptors. Current Opinion in Cell Biology, 8(4), 484-489.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Glutamate receptor-interacting protein」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.